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A variety of media, supplemental media components, and reagents suitable for cell culture operations and processes. Products include fully prepared media as well as antibiotics, growth factors, contamination detection and removal reagents, cell dissociation reagents, and more.
A number of modifications of Graces medium were developed in several laboratories in the late 1960s and 1970s. Many of these modifications were developed by Dr. W.f. Hink for the growth of cells derived from the cabbage looper Tricoplusia ni. This formula represents the modification known as TNM-fH. The medium when properly supplemented has been found to support the growth of cells derived from a variety of lepidopteran species.
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The most basic formulation offered. This formulation is used by investigators who want to start with the essential components of DME and have the flexibility to optimize the formula for their own application.
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Tobramycin sulfate is a broad-spectrum aminoglycoside antibiotic administered parenterally. It is commonly used in the treatment of moderate to severe bacterial infections caused by sensitive organisms and can be utilized in pneumonia research specifically related to Pseudomonas aeruginosa.
Targets aminoglycoside
Decreases P. aeruginosa cell viability in combination with Mycobacterium fortuitum enzyme
Produces bacterial cell kill effect in murine pneumonia models
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that exhibits anti-infective activity by binding to 30s and 70s ribosomes, without affecting the 50s subunit. Its mechanism involves mimicking mRNA nucleotides, which consequently disrupts tRNA binding and hinders canonical translation initiation. This compound has also been observed to enhance the sensitivity of mycobacteria to Rifampicin in both in vitro settings and mouse infection models.
Inhibits P-site tRNA binding by destabilizing mRNA.
Decreases mistranslation rates of asparagine-to-aspartate and glutamine-to-glutamate.
Reduces mycobacterial rifampicin phenotypic resistance in wild-type and high mistranslating gatA mutant mycobacterial strains.
Leads to rapid clearance of *M. tuberculosis* in lung burden in Mtb-infected mice.
Increases Rifampicin susceptibility by 30-fold.
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Basal salt mixture containing micro and macro elements with vitamins as described by Linsmaier & Skoog (1965). Package contains 4.4 grams of powder per liter of medium. Hygroscopic.
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